Citation:
Faust O., L., Bigman , and A., Friedler . 2014. “A Role For A Disordered Domain In Regulating Protein Oligomerization And Stability”. Chem. Comm. https://pubs.rsc.org/en/content/articlelanding/2014/cc/c4cc03863k#!divAbstract.
Abstract:
Intrinsically disordered proteins (IDPs) or regions (IDRs) in proteins hold many functions but their biological roles are still not fully understood. Here we describe a new role of such regions. Using the HIV-1 Rev protein, we show that disordered domains have a role in maintaining the correct oligomeric state and the thermodynamic stability of proteins.