Monitoring the HIV-1 Integrase Enzymatic Activity Using Atomic Force Microscope in a 2LTR

Citation:

Guy S., D., Rotem , Z., Hayouka , R., Gabizon , L., Zemel , A., Loyter , D., Porath , and A., Friedler . 2013. “Monitoring The Hiv-1 Integrase Enzymatic Activity Using Atomic Force Microscope In A 2Ltr”. Chemcomm. https://pubs.rsc.org/en/content/articlelanding/2013/CC/c3cc40748a.

Abstract:

Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.