Welcome to Assaf Friedler's lab page

ברוכים הבאים לאתר המעבדה של אסף פרידלר

 

Our lab is a part of the Institute of Chemistry at the Hebrew University of Jerusalem.

We are an interdisciplinary team focusing on the study of protein-protein interactions, peptide inhibitors/activators, peptide and protein chemistry, biophysics, chemical biology and medicinal chemistry (see more).

Prof. Friedler is the Dean of the Faculty of Science of the Hebrew University.

 

We are looking for talented Chemists, Microbiologists and Bioengineers to come develop next generation cellular agriculture with us! 

For more information, Email Assaf!

 

 

Follow us on Twitter @FriedlerLab 

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  • Kinase Sensing Based on Protein Interactions at the Catalytic Site

    Kinase Sensing Based on Protein Interactions at the Catalytic Site, Chem. Eur. J. 2022

  • Covalent Inhibition of HIV-1 Integrase by N-Succinimidyl Peptides

    Covalent Inhibition of HIV-1 Integrase by N-Succinimidyl Peptides, ChemMedChem 2016

  • Targeting an Interaction Between Two Disordered Domains by Using a Designed Peptide

    Targeting an Interaction Between Two Disordered Domains by Using a Designed Peptide, Chem. Eur. J. 2020

  • Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein

    Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein, Chem. Sci. 2016

  • Using peptides to inhibit protein-protein interactions

    Using peptides to inhibit protein-protein interactions

  • Osmolytes and crowders regulate aggregation of the cancer-related L106R mutant of the Axin protein

    Osmolytes and crowders regulate aggregation of the cancer-related L106R mutant of the Axin protein, Biophys. J. 2021

  • Peptides as drug targets

    Peptides as drug targets

  • A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of phosphorylation patterns in proteins

    A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of, Org. Biomol. Chem. 2019

  • Electrochemical biosensors based on peptide-kinase interactions at the kinase docking site

    Electrochemical biosensors based on peptide-kinase interactions at the kinase docking site, Biosens. Bioelectron. 2022

  • The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells

    The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells, Chem. Sci. 2019

  • Highly homologous proteins exert opposite biological activities by using different interaction interfaces

    Highly homologous proteins exert opposite biological activities by using different interaction interfaces, Sci. Rep. 2015

  • Automated Synthesis of Heavily Phosphorylated Peptides

    Automated Synthesis of Heavily Phosphorylated Peptides, Eur. J. Org. Chem. 2021

  • Regulation of ASPP2 Interaction with p53 Core Domain by an Intramolecular Autoinhibitory Mechanism

    Regulation of ASPP2 Interaction with p53 Core Domain by an Intramolecular Autoinhibitory Mechanism, PLoS ONE 2013

  • Using peptides to revert the oligomerization of the intrinsically disordered region of STIL

    Using peptides to revert the oligomerization of the intrinsically disordered region of STIL

  • Structured-disordered interactions

    Structured-disordered interactions

  • A peptide-derived strategy for specifically targeting the mitochondria and ER of cancer cells: a new approach in fighting cancer. Chem Sci. 2022

    A peptide-derived strategy for specifically targeting the mitochondria and ER of cancer cells: a new approach in fighting cancer

  • Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors. ACS Chemical Biology. 2022
  • Accelerated Multiphosphorylated Peptide Synthesis

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Journal Covers

Angew. Chem. Int. Ed. 2014guy

Med. Chem. Comm. 2014
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Org. Biomol. Chem. 2014
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ChemMedChem 
2016

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Chem. Sci.
2019

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Org. Biomol. Chem. 2019
mhfsn

Chem. Eur. J. 
2020

vfs

Chem. Eur. J. 
2022

vfsbv

ACS Chemical Biology
2022

 

 

Minerva

 

The Friedler group is part of the Minerva Center for Bio-Hybrid Complex Systems